Studying the influence of plant complexes on biochemical parameters and morphological picture of organs
and tissues in experimental atherosclerosis 

Maria N. Zamotaeva, Candidate of medical sciences, associate professor, associate professor of the sub-department of pharmacology and clinical pharmacology with a course in pharmaceutical technology, Medical Institute, Ogarev Mordovia State University (68 Bolshevistskaya street, Saransk, Russia), zamy03@mail.ru
Ivan N. Chairkin, Doctor of medical sciences, professor, professor of the sub-department of human anatomy, Institute of Anatomy and Morphology named after Academician Yu.M. Lopukhin, Russian National Research Medical University named after N.I. Pirogov (1 Ostrovityanova street, Moscow, Russia), chairkin@rambler.ru
Natalya V. Chairkina, Doctor of medical sciences, professor, associate professor of the sub-department of pathological anatomy and clinical pathological anatomy, Institute of Human Biology and Pathology, Russian National Research Medical University named after N.I. Pirogov (1 Ostrovityanova street, Moscow, Russia)
Aleksandr V. Siprov, Doctor of medical sciences, professor, head of the sub-department of pharmacology and clinical pharmacology with a course in pharmaceutical technology, Medical Institute, Ogarev Mordovia State University (68 Bolshevistskaya street, Saransk, Russia), alek-s13@mail.ru
Yulia V. Maltseva, Resident of the sub-department of hospital therapy, Medical Institute, Ogarev Mordovia State University (68 Bolshevistskaya street, Saransk, Russia), julyy-y@mail.ru

 Background. Study of changes in biochemical and morphological parameters in rats with experimental atherosclerosis and the influence of plant complexes on them. Mate rials and methods. On a cholesterol model of atherosclerosis in rats, the hypolipidemic, hy poglycemic, cardioprotective, and hepatoprotective effects of plant complexes were stud ied: 1^st – based on garlic and beetroot, 2^nd – based on dioscorea, hawthorn, red clover, and beetroot, 3^rd – based on thyme, blueberry, horsetail, and rose hips. Results. It was found that the most effective herbal complex for hyperlipidemia with elevated levels of low-density lipoproteins was based on blueberries, and for hypertriglyceridemia - based on garlic. All the studied herbal complexes have a hepatoprotective and cardioprotective effect, improv ing the biochemical parameters and morphological picture of liver and heart tissue in ather osclerosis, and also normalize uric acid metabolism. The herbal complex based on garlic has a pronounced sugar-lowering effect. Possible mechanisms of action of the studied herb al complexes are discussed. Conclusions. The obtained results indicate the presence of high hypolipidemic activity and pleiotropic effects in plant complexes based on garlic, blueber ries and dioscorea.

atherosclerosis, hyperlipidemia, herbal picking, herbal remedy, medicinal plants

Zamotaeva M.N., Chairkin I.N., Chairkina N.V., Siprov A.V., Maltseva Yu.V. Studying the influence of plant complexes on biochemical parameters and morphological picture of organs and tissues in experimental atherosclerosis. Izvestiya vysshikh uchebnykh zavedeniy. Povolzhskiy region. Meditsinskie nauki = University proceedings. Volga region. Medical sciences. 2025;(2):145–153. (In Russ.). doi: 10.21685/2072-3032-2025-2-13